Tissue transglutaminase in fibrosis — more than an extracellular matrix cross-linker
نویسندگان
چکیده
منابع مشابه
Extracellular volume fraction provides more imformation than fibrosis
Background Extracellular volume fraction (ECV) has been applied to the detection of diffuse myocardial interstitial fibrosis or exudative pathologic changes in various clinical settings, but there is lack of study to date concerning the significance of ECV at the early phase of left ventricular remodeling. We intended to assess myocardial ECV in essential hypertension and to study the implicati...
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Cerebral amyloid angiopathy (CAA) is a key histopathological hallmark of Alzheimer's disease (AD) and hereditary cerebral hemorrhage with amyloidosis of the Dutch type (HCHWA-D). CAA is characterized by amyloid-beta (Aβ) depositions and remodeling of the extracellular matrix (ECM) in brain vessels and plays an important role in the development and progression of both AD and HCHWA-D. Tissue tran...
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PURPOSE Proliferative vitreoretinopathy (PVR) is characterized by the development of epi- and subretinal fibrocellular membranes containing modified retinal pigment epithelial (RPE) cells among others. In the present study, the role of transglutaminases in accumulation of extracellular matrix (ECM) proteins in these membranes was investigated. Transglutaminases are enzymes capable of cross-link...
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Extracellular matrix mass balance is implied in many physiological and pathological events, such as metastasis dissemination. Widely studied, its destructive part is mainly catalysed by extracellular proteinases. Conversely, the properties of the constructive part are less obvious, cellular neo-synthesis being usually considered as its only element. In this paper, we introduce the action of tra...
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ژورنال
عنوان ژورنال: Current Opinion in Biomedical Engineering
سال: 2019
ISSN: 2468-4511
DOI: 10.1016/j.cobme.2019.06.003